Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery.

ABSTRACT:

Purpose

There is currently limited information regarding inflammation and cytokine levels in the aqueous humor (AH) of adult patients with cataract who have undergone phacoemulsification cataract extraction without other ocular comorbidities.

Methods

AH samples were collected from healthy, non-surgical donors and donors with a history of cataract surgery performed 3 to 12 years prior. Sixty-three cytokines and growth factors were measured using bead-based ProcartaPlex immunoassays. Data analysis included normal distribution assessment, pairwise correlation, logistic regression, and ridge regression.

Results

Of the 63 molecules analyzed, 34 were selected for further study. Cytokines, such as CD40L, IL-7, MIP-1α, and LIF, were found at significantly higher concentration

SUBMITTER: Hao C 

PROVIDER: S-EPMC11977793 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature