Relative Exchangeable Copper, Exchangeable Copper and Total Copper in the Diagnosis of Wilson Disease.

ABSTRACT:

Background and aims

Diagnosing Wilson disease (WD) remains challenging. The exchangeable copper (CuEXC) methodology measures the non-ceruloplasmin-bound copper fraction in serum. Relative exchangeable copper (REC), the ratio of CuEXC to total serum copper (Total Cu), has been proposed as a potential diagnostic biomarker. This study aimed to evaluate the diagnostic performance of these three copper biomarkers in WD.

Methods

CuEXC and Total Cu levels were measured in newly diagnosed treatment-naïve patients with WD (n = 13), treated WD (n = 91), non-Wilsonian hepatic disease (n = 206) and non-Wilsonian acute liver failure (n = 22). REC, CuEXC and Total Cu were compared among groups. Receiver-operating characteristic analyses were performed.

Results

Median REC was signif

SUBMITTER: Lorenzen C 

PROVIDER: S-EPMC11977851 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature