Association between erythritol and lung cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Sweeteners have been widely added to food and beverages due to their low-calorie and sweetening properties. However, the role of sweeteners in cancer risk has been a subject of extensive debate over the past few decades.

Objective

We aimed to elucidate the causation between the commonly used natural sweetener erythritol and the risk of lung cancer (LC) using Mendelian randomization (MR).

Methods

Data on erythritol and its metabolites were obtained from publicly available genome-wide association studies data. Summary data on LC and its subtypes were obtained from a large-scale genetic study conducted by the Transdisciplinary Research of Cancer in Lung of the International Lung Cancer Consortium and the Lung Cancer Cohort Consortium. We conducted independent

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11978034 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature