Brain alterations and neurologic disorder progression induced by lymphatic dysfunction in the head and neck region.

ABSTRACT: The potential negative impact of lymphatic dysfunction caused by head and neck cancer treatment remains underexplored. Emerging evidence suggests that waste clearance and fluidic balance in the brain are connected to the peripheral lymphatic system in the head and neck region, implying that lymphatic injury in this area could contribute to brain damage. This study aimed to investigate the pathological alterations in the brain induced by peripheral lymphatic dysfunction in the head and neck region using the lymphatic obstruction animal model. An animal model underwent cervical lymph node dissection combined with radiation therapy to simulate the condition with the peripheral lymphatic dysfunction in the head and neck region after cancer treatment. Lymphatic drainage impairment in the head a

SUBMITTER: Cheon H 

PROVIDER: S-EPMC11978131 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature