Prenatal organophosphate pesticide exposure and sex-specific estimated fetal size.

ABSTRACT: Prenatal organophosphate (OP) pesticide exposure may be associated with reduced fetal growth, although studies are limited and have mixed results. We investigated associations between prenatal OP pesticide exposure and fetal size and modification by fetal sex. Maternal urinary concentrations of dialkyl phosphate (DAP) metabolites were measured at 3 time points. Fetal biometrics were obtained from ultrasounds in the second (n = 773) and third (n = 535) trimesters. Associations between pregnancy-averaged ΣDAP and fetal biometry z scores were determined through multiple linear regression. Modification by sex was investigated through stratification and interaction. In the second trimester, one ln-unit increase in ΣDAP was associated with lower estimated fetal weight (-0.15 SD; 95% CI, -0.29 to

SUBMITTER: Medley EA 

PROVIDER: S-EPMC11978611 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature