Ticagrelor or dipyridamole plus aspirin may be a promising antiplatelet therapy in patients with minor stroke or transient ischemic attack: a bayesian network meta-analysis.

ABSTRACT:

Background

The efficacy and safety of different antiplatelet in minor strokes or transient ischemic attacks (TIAs) remains controversial.

Methods

We searched PubMed, Embase, Web of Science and the Cochrane Library to identify all eligible articles until 12 September 2024. Efficacy outcomes were all-cause mortality, excellent outcome, functional independence and recurrent stroke. Safety outcomes were any types of bleeding and intracerebral hemorrhage (ICH). The associations were calculated for the overall data by using the odds ratios (ORs).

Results

12 high-quality studies with 10 RCTs and 2 Non-RCTs were included, involving 61,281 patients with minor strokes or TIAs. Ticagrelor + Aspirin was significantly more effective than Clopidogrel + Aspirin in preventing post-st

SUBMITTER: Qin S 

PROVIDER: S-EPMC11978618 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature