Association between bone mineral density and stroke: a meta-analysis.

ABSTRACT:

Objective

The correlation between bone mineral density (BMD) and stroke remains inconsistent. This study aims to determine whether a reduction in BMD is associated with an increased risk of stroke.

Methods

We systematically searched Medline, Embase, and the Cochrane Database of Systematic Reviews through January 2025 to identify cohort studies with follow-up that reported the influence of a reduction in BMD or low BMD status on the risk of any type of stroke. Pooled analyses were performed using random-effects models.

Results

This study included 13 studies with 146,758 individuals. A 1 SD reduction in BMD was associated with an increased risk of stroke (eight studies; RR, 1.24; 95% CI, 1.09-1.40; p < 0.001; I² = 87%). Subgroup analysis showed that a

SUBMITTER: Zhao P 

PROVIDER: S-EPMC11978661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature