Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease.

ABSTRACT: A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies. We analyzed paraffin-embedded gastric tissue samples from 326 patients. A20 expression was assessed using immunohistochemistry (IHC) with results categorized according to the Remmele and Stegner immunoreactive score (IRS). The study compared A20 expression across a sp

SUBMITTER: Schnizler S 

PROVIDER: S-EPMC11978676 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature