Exploring the causal role of the human gut microbiome in endometrial cancer: a Mendelian randomization approach.

ABSTRACT: Endometrial cancer presents a major public health issue, particularly in post-menopausal women. Whilst there are known risk factors for the disease, including oestrogen and obesity, these factors do not fully explain risk variability in cancer outcomes. The identification of novel risk factors may aid in better understanding of endometrial cancer development and, given the link with oestrogen metabolism, obesity and the risk of various cancers, the gut microbiome could be one such risk factor. Mendelian randomization (MR), a method that reduces biases of conventional epidemiological studies (namely, confounding and reverse causation) by using genetic variants to proxy exposures, was used to investigate the effect of gut microbial traits on endometrial cancer risk. Whilst our initial analys

SUBMITTER: Fryer E 

PROVIDER: S-EPMC11978776 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature