Colloidal-fibrillar composite gels demonstrate structural reinforcement, secondary fibrillar alignment, and improved vascular healing outcomes.

ABSTRACT: Many biological tissues contain colloids within a fibrillar structure. Here, we develop and characterize colloidal-fibrillar scaffolds through examination of the effects of relative colloid and fiber ratios within a fibrin-based model system composed of fibrin-based nanoparticles (FBNs) within a natural fibrin scaffold. At lower concentrations, FBNs primarily integrate into the fibrillar fibrin matrix, strengthening it. At high concentrations, colloid-colloid interactions dominate and FBNs primarily form a highly aligned secondary structure that does not strengthen the fibrillar matrix. At intermediate concentrations, both reinforcement of the fibrin matrix and colloid-colloid interactions are observed. Our characterization of this colloidal-fibrillar system provides insight into new avenu

SUBMITTER: Moiseiwitsch NA 

PROVIDER: S-EPMC11978784 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature