<i>Astragalus mongholicus</i> <i>bunge</i> and <i>Angelica sinensis</i> botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling.

ABSTRACT:

Introduction

Astragalus mongholicus bunge and Angelica sinensis are botanical drugs rich in beneficial nutrients and health-promoting metabolites. Their roots can be decocted to a botanical drug decoction "Danggui Buxue Tang (DBT)," demonstrating human anti-inflammatory.

Methods

Here, we evaluate the mitigating function of DBT on lung inflammation and early fibrosis in a rat model. The model was established by tracheal dripping of silica suspension for 28 days. Positive intervention effects of DBT were observed in a dose-dependent manner after consecutive gavage of DBT (1.9, 3.8, and 7.6 g/kg·bw/d) for 28 days and 42 days. To explore the underlying molecular mechanism. DBT metabolites were profiled using a liquid chromatograph-mass spectrometer and the Chemspid

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11978833 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature