A causal effects of neutrophil extracellular traps and its biomarkers on acute respiratory distress syndrome: a two-sample Mendelian randomization study.

ABSTRACT: Previous studies have indicated an association between neutrophil extracellular traps (NETs) and acute respiratory distress syndrome (ARDS). This study aimed to investigate the potential causal effects of NETs and NETs-related biomarkers on ARDS or vice-versa. A two-sample Mendelian randomization (MR) utilizing genome-wide association studies (GWAS) data was employed to analyze the causality. The primary analysis was conducted using inverse-variance weighted (IVW) methods; weighted median, MR-Egger, and weighted model methods were used to validate the results. Horizontal pleiotropy and outlier detection were assessed via MR-Egger and MR pleiotropy residual sum and outlier (MR-PRESSO), respectively; Cochran's Q test evaluated heterogeneity, while Leave-one-out analyses were used to evaluate

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11978891 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature