Molecule subtypes play important roles for second primary malignancies development based on 324,661 breast cancer survivors.

ABSTRACT: The incidence trend of breast molecule subtypes was unclear. There was not quantified risk by subtype with the second primary malignancies (SPMs) and limited evidence about the risk factors for developing SPMs in first primary breast cancer(FPBC). Data from 18 SEER registries were used to identify FPBC, which were randomly selected for training and validation sets. The SPMs information of breast cancer survivors in Hebei were also collected to compare the distribution with SEER. Univariate and multivariate analysis were performed to explore the risk factors and integrated to the establishment of nomogram and risk stratification model. There was a decreased trend for TNBC, but an increased trend for Luminal A. The median survival months were 46, 46, 46 and 44 for Luminal A, Luminal B, HER2

SUBMITTER: Shi J 

PROVIDER: S-EPMC11978904 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature