Boosting working memory in the elderly: driving prefrontal theta-gamma coupling via repeated neuromodulation.

ABSTRACT: The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to stabilize or enhance cognitive functions. Deficits in working memory (WM) are linked to alterations in prefrontal theta-gamma cross-frequency coupling. Low-intensity transcranial alternating current stimulation (tACS) has emerged as a non-invasive, low-cost approach capable of modulating ongoing oscillations in targeted brain areas through entrainment. This study investigates the impact of multi-session peak-coupled theta-gamma cross-frequency tACS administered to the dorsolateral prefrontal cortex (DLPFC) on WM performance in older adults. In a randomized, sham-controlled, triple-blinded design, 77 participants underwent 16 stimulation sessions ov

SUBMITTER: Diedrich L 

PROVIDER: S-EPMC11979004 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature