Plasma extracellular vesicles carry immune system-related peptides that predict human longevity.

ABSTRACT: Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to identify circulating extracellular vesicle (EV) biomarkers indicative of longevity. The plasma EV proteome of 48 older adults (mean age 77.2 ± 1.7 years [range 72-80]; 50% female, 50% Black, 50% < 2-year survival, 50% ≥ 10-year survival) was analyzed by high-resolution mass spectrometry and flow cytometry. The ability of EV peptides to predict longevity was evaluated in discovery (n = 32) and validation (n = 16) datasets with areas under receiver operating characteristic curves (AUCs). Longevity-associated large EV (LEV) plasma subpopulations were mainly related to immune cells (HLA-ABC⁺, CD9⁺, and CD31⁺) and muscle cells (MCAD⁺

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11979029 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature