Effect of sheep placenta extract on D-galactose-induced aging mouse.

ABSTRACT:

Introduction

Sheep placenta extract (SPE) is a representative traditional medicinal substance that exhibits multiple experimentally validated physiological properties, including anti-aging effects, wound healing acceleration, antioxidant activity, and anti-inflammatory mechanisms. However, the mechanism by which SPE influences the delay of aging is still not yet clear.

Methods

Exploring the effects of sheep placenta extract on D-gal induced senescence in a mouse model of aging by macrogenomics and metabolomics.

Results

In the serum of aging mice treated with SPE, the levels of antioxidant function such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were notably higher compared to those in the blank group, whereas malondialdehyde (MD

SUBMITTER: He S 

PROVIDER: S-EPMC11979192 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature