<i>Streptomyces</i> sp. VITGV156 secondary metabolite binds pathogenic protein PBP2a and Beta-lactamase.

ABSTRACT:

Introduction

The genus Streptomyces is renowned for its prolific production of bioactive compounds, including antibiotics and secondary metabolites with pharmaceutical applications. This study focuses on Streptomyces sp. VITGV156, an isolate with promising antimicrobial properties, aiming to characterize its genomic potential and bioactive compounds through computational and experimental analyses.

Methods

Genomic sequencing of Streptomyces sp. VITGV156 was performed to identify biosynthetic gene clusters (BGCs) associated with secondary metabolite production. Antimicrobial assays were conducted using crude extracts against Gram-positive and Gram-negative pathogens. Gas Chromatography-Mass Spectrometry (GC-MS) was employed to identify secondary metabolite

SUBMITTER: Pattapulavar V 

PROVIDER: S-EPMC11979255 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature