Kunxinning granules alleviate perimenopausal syndrome by supplementing estrogen deficiency.

ABSTRACT:

Introduction

Ovarian function decline results in reduced estrogen levels, leading to endocrine disorders, oxidative stress damage, and excessive activation of inflammatory factors, all of which contribute to the development of premenstrual syndrome (PMS). Kunxinning Granules (KXN) has been clinically approved for PMS treatment, but its bioactive ingredients and mechanism of action remain unclear. This study aimed to investigate the active metabolites and molecular mechanism of KXN in treating PMS rats, laying a foundation for the clinical development of PMS treatment.

Methods

An ovariectomized (OVX) rat model was established to evaluate the efficacy of KXN in treating PMS. Molecular network (MN) analysis, combined with UPLC/Q-TOF-MS, identified prototype compounds in the sam

SUBMITTER: Wang W 

PROVIDER: S-EPMC11979375 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature