Incidence, prevalence, and mortality of localized scleroderma in Quebec, Canada: a population-based study.

ABSTRACT:

Background

Localized scleroderma is an understudied autoimmune disease characterized by fibrosis of the skin and/or subcutaneous tissue. To date, only 6 articles reported on the incidence and/or prevalence estimates globally, with significant design limitations and risk of bias. None of the studies originated from Canada or investigated mortality/geospatial epidemiology. We aimed to study the incidence, prevalence, mortality and spatiotemporal trends of localized scleroderma in Quebec, Canada, stratified by sex and age.

Methods

Quebec populational health administrative databases were used to identify localized scleroderma cases from 1989 to 2019. Crude incidence rate, age-standardized incidence rate, prevalence and mortality analyses were conducted using negative binomial ra

SUBMITTER: Ghazal S 

PROVIDER: S-EPMC11979410 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature