Lower functional connectivity state transitions during affective processing correlate with subsequent impairment in sustaining positive affect in subthreshold depression.

ABSTRACT:

Background

Diminished capacity for maintaining positive affect (PA) has been identified in subthreshold depression (StD). While recent studies have explored affective dynamics among StD, the relationship between early emotional processing impairments and the capacity to prolong PA remains uncertain. Furthermore, it is unclear how brain connectivity patterns observed in StD are associated with PA maintenance.

Methods

The experimental procedure comprised a baseline rs-fMRI scan, followed by a PA-inducing movie viewing task, and three further rs-fMRI sessions. Participants provided PA ratings following each session. PA maintenance was quantified through the slope of mood change between each session after movie viewing. We performed a dynamic functional connectivity analysis on

SUBMITTER: Song X 

PROVIDER: S-EPMC11979472 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature