End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration.

ABSTRACT: Despite an increasing number of tissue-engineered scaffolds have been developing for bone regeneration, simple and universal fabrication of biomimetic bone microstructure to repair full-thickness bone defects remains a challenge and an acute clinical demand due to the negligence of microstructural differences within the cortex of cancellous bone. In this work, a biomimetic sandwich-layered PACG-CS@Mn(III) hydrogel (SL hydrogel) was facilely fabricated in an end-tail soaking strategy by simply post-crosslinking of poly(acryloyl 2-glycine)-chitosan (PACG-CS) composite hydrogel using trivalent manganese solutions. Taking the merits of in-situ formation and flexible adjustment of chain entanglements, hydrogen bonds and metal chelate interactions, SL hydrogel with sandwich-like three-lay

SUBMITTER: Shan J 

PROVIDER: S-EPMC11979482 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature