Identification of Common Brain Protein and Genetic Loci Between Parkinson's Disease and Lewy Body Dementia.

ABSTRACT:

Background

Parkinson's disease (PD) and Lewy body dementia (LBD) have many common features, including clinical manifestations, neurochemistry, and pathology, but little is known about their shared brain proteins and genetic factors.

Methods

To identify susceptibility-related brain proteins that are shared between PD and LBD patients, proteome-wide association studies (PWASs) were conducted by integrating human brain protein quantitative trait loci (pQTLs) with large-scale genome-wide association studies (GWASs) of both diseases. Subsequently, pleiotropy-informed conditional false discovery rate (pleioFDR) analysis was performed to identify common risk genetic loci between PD and LBD. Finally, the downregulation of these risk genes in different disease states was validated by

SUBMITTER: Jia T 

PROVIDER: S-EPMC11979625 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature