A Proteomic Signature for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma Predicts Patients at High Risk of Recurrence.

ABSTRACT:

Abstract

Although human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with better prognosis than HPV-negative disease, ∼30% of cases relapse despite curative-intent radiotherapy (±chemotherapy). We aimed to develop a proteomic signature associated with risk of recurrence within HPV+OPSCC. We analyzed tumor specimens from 124 patients with T1–4N0–3M0 HPV+OPSCC: 50 patients with residual or recurrent disease within 5 years of treatment and 74 age and performance status–matched patients with no recurrence. Proteomic analysis was performed on archival formalin-fixed, paraffin-embedded primary tumor core biopsy specimens and matched normal adjacent tissues using quantitative data-independent acquisition mass spectrometry. Recurrence-free survi

SUBMITTER: Jackson CC 

PROVIDER: S-EPMC11979894 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature