GC-MS/MS-based multiresidue pesticide analysis in mealworm (<i>Tenebrio molitor</i>) larvae: Optimization of standard QuEChERS-based method to minimize matrix effects.

ABSTRACT: Given the unsuitability of the standard quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based method for multiresidue pesticide analysis in mealworm larvae due to their complex composition and high lipid content, we established a gas chromatography-tandem mass spectrometry-based procedure for the detection and quantitation of 247 pesticides in this matrix. The optimized extraction solvent (0.1 % formic acid in acetonitrile) was combined with the original QuEChERS salt packet to achieve high recovery rates, and matrix-derived interferents were effectively removed without analyte loss using primary secondary amine-based dispersive solid-phase extraction (cleanup step). Acceptable linearities, high recoveries, and low detection limits were achieved for most analytes. The detection

SUBMITTER: Noh HH 

PROVIDER: S-EPMC11979949 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature