An Electroencephalogram Signature of Melanin-Concentrating Hormone Neuron Activities Predicts Cocaine Seeking.

ABSTRACT:

Background

Identifying biomarkers that predict substance use disorder propensity may better strategize antiaddiction treatment. Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus critically mediate interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers.

Methods

Surface EEG signals and real-time calcium (Ca²⁺) activities of lateral hypothalamus MCH neurons (Ca²⁺_MCH) were simultaneously recorded in male and female adult rats. Mathematical modeling and machine learning were then applied to predict Ca²⁺_MCH using EEG derivatives. The robustness of the predictions was tested across

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11979969 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature