Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes.

ABSTRACT:

Background

Psoriasis is a chronic, immune-mediated inflammatory skin disorder with a strong genetic component. Although numerous GWAS have identified risk loci, many associated variants lie in non-coding regions, complicating functional interpretation.

Objective

This study aimed to identify novel psoriasis susceptibility genes by integrating large-scale GWAS and eQTL data using a cross-tissue TWAS approach.

Methods

We integrated psoriasis GWAS summary statistics from the FinnGen database with GTEx V8 eQTL data. A cross-tissue TWAS was performed using UTMOST, followed by validation with single-tissue TWAS via FUSION. Conditional and joint analyses were conducted to delineate independent genetic signals, and gene-based analysis was performed using MAGMA. Causal relation

SUBMITTER: Yan F 

PROVIDER: S-EPMC11979975 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature