Coding Variants of the Genitourinary Development Gene <i>WNT9B</i> Carry High Risk for Prostate Cancer.

ABSTRACT:

Purpose

Considerable genetic heterogeneity is currently thought to underlie hereditary prostate cancer (HPC). Most families meeting criteria for HPC cannot be attributed to currently known pathogenic variants.

Methods

To discover pathogenic variants predisposing to prostate cancer, we conducted a familial case-control association study using both genome-wide single-allele and identity-by-descent analytic approaches. Sequence of high-risk haplotype carriers was used for variant detection. Candidate pathogenic variants were tested for association with prostate cancer across independent biobanks for replication of observations.

Results

Pathogenic variants within WNT9B were associated with familial prostate cancer and observations replicated within four of four ind

SUBMITTER: Dupont WD 

PROVIDER: S-EPMC11980042 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature