The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks.

ABSTRACT:

Background

Spatial and temporal control of DNA damage response pathways after DNA damage is crucial for maintenance of genomic stability. Ataxia telangiectasia mutated (ATM) protein plays a central role in DNA damage response pathways. The chain of events following induction of DNA damage that results in full activation of ATM is still evolving. Here we set out to explore the role of CREB-binding protein (CBP), a histone acetyltransferase (HAT), in DNA damage response, particularly in the ATM activation pathway.

Results

In response to DNA damage, CBP is stabilized and is recruited at sites of DNA double-strand breaks where it acetylates ATM and promotes its kinase activity. Cells deficient in CBP display an impairment in DNA double-strand break repair and high sensitivity to

SUBMITTER: Ramadan WS 

PROVIDER: S-EPMC11980100 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature