Association between cardiorespiratory fitness and total brain myelin volume among older adults.

ABSTRACT:

Background

Myelin, which insulates neurons, speeds up information transfer and provides the necessary conditions for cognitive and motor functioning. The direct link between physical performance and the total brain myelin volume remains unclear.

Methods

This study involved 87 healthy participants (71 women, 16 men) with a mean age of 69.3 ± 3.14 years and a mean body mass index of 27.83 ± 3.93 kg/m². Several measures of physical fitness (isometric muscle strength, handgrip strength, and cardiopulmonary exercise testing) were examined for their correlations with the total brain myelin volume using Synthetic MRI, an FDA-approved myelin assessment software.

Results

A high maximal respiratory exchange ratio and low maximal heart rate achieved during cardiopulmo

SUBMITTER: Kujawa MJ 

PROVIDER: S-EPMC11980140 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature