Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Recent studies have indicated a connection between plasma metabolites and Post-traumatic stress disorder (PTSD). Nevertheless, the precise causal relationship remains unclear.

Methods

We performed bidirectional Mendelian Randomization (MR) using two metabolite and two PTSD GWAS datasets to examine causal relationships between PTSD and 1009 plasma metabolites. Forward MR tested metabolite causally effects on PTSD, while reverse MR assessed PTSD causally effects on metabolites. Primary analysis employed the IVW method, supported by four supplementary methods. Four IVW results per direction were meta-analyzed to identify high-credibility metabolites. Venn diagrams intersected results from the four IVW analyses, and this intersection was further compared with meta-ana

SUBMITTER: Yao X 

PROVIDER: S-EPMC11980153 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature