Bile acid metabolism in multiple sclerosis is perturbed and associated with the risk of confirmed disability worsening.

ABSTRACT:

Background

Bile acids (BAs) have emerged as important mediators in neuroinflammation and neurodegeneration, important features of multiple sclerosis (MS). This study aimed to examine serum BA levels in newly diagnosed people with MS (pwMS) and explore their association with disability worsening.

Methods

The study included 907 pwMS and 907 matched controls from the Swedish population-based EIMS cohort, with clinical follow-up data from the Swedish MS Registry. Serum BA levels were analyzed using liquid chromatography-high-resolution mass spectrometry. Differential expression analysis was used to study differences in BAs between pwMS and controls. Cox proportional-hazard models were used to assess associations between BA concentrations and confirmed disability worsening (CDW)

SUBMITTER: Erngren I 

PROVIDER: S-EPMC11980154 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature