Impact of complement C3 levels on the development of healthcare-associated infections in intensive care patients: a retrospective case-control study.

ABSTRACT:

Purpose

The immune system serves as a critical line of defence against pathogenic microorganisms. To investigate the impact of immune markers, measured within the first 48 h of intensive care unit (ICU) admission, on the incidence of healthcare-associated infections (HAIs) in ICU patients.

Methods

This case-control study included 364 patients admitted from 1 January 2020 to 30 November 2023, receiving immune marker testing within 48 h of ICU admission. Cox proportional hazard models and propensity score matching evaluated immune markers' association with HAIs risk. Log-rank tests compared time-to-event by C3 levels. All data processing and analysis were performed using R version 4.2.0 (R Foundation for Statistical Computing, Vienna, Austria) and Python version 3.11 (Python S

SUBMITTER: Wang C 

PROVIDER: S-EPMC11980203 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature