Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells.

ABSTRACT:

Backgrounds

The interplay between intestinal epithelial cells (IECs), the immune system, and the gut microbiome is pivotal for maintaining gastrointestinal homeostasis and mediating responses to ingested antigens. IECs, capable of expressing Major Histocompatibility Complex (MHC) class II molecules, are essential in modulating immune responses, especially CD4 + T cells, in both physiological and pathological contexts. The expression of MHC class II on IECs, regulated by the class II transactivator (CIITA) and inducible by cytokine IFN-γ, has been traditionally associated with professional antigen-presenting cells but is now recognized in the context of inflammatory conditions such as inflammatory bowel disease (IBD). In veterinary medicine, particularly among canine populations, MH

SUBMITTER: Nakazawa M 

PROVIDER: S-EPMC11980282 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature