Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV₁% ≥80% predicted.

ABSTRACT:

Objective

To explore the differentiation of airway inflammation, bronchial hyperresponsiveness and anti-asthma therapy responses between the cough variant asthma (CVA) and classic asthma (CA) patients with FEV₁% ≥80% predicted.

Methods

In the first monocentre retrospective cross-sectional study, 402 patients with suspicion of CA and 544 patients with chronic cough were enrolled. Further prospective monocentre study was conducted and 66 patients of suspected asthma with negative bronchial dilation test (BDT) but positive bronchial challenge (BCT) test were enrolled and followed up for 4 weeks.

Results

CA patients had higher fractional exhaled nitric oxide (FENO) values than CVA patients (36.0 ppb vs. 24.0 ppb, p < 0.0001). The predictive value of FENO for po

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11980309 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature