HilD-regulated chemotaxis proteins contribute to <i>Salmonella</i> Typhimurium colonization in the gut.

ABSTRACT: In the enteric pathogen Salmonella Typhimurium, invasion and motility are coordinated by HilD, a master regulator that activates expression of genes encoding the type III secretion system 1 and some motility genes, including the chemotaxis gene mcpC. Previously, we have shown that McpC induces smooth swimming, which is important for type III secretion system 1-dependent invasion of epithelial cells. Here, we have studied another Salmonella-specific chemotaxis gene, mcpA, and demonstrate that it is also HilD regulated. Whereas HilD induction of mcpC occurs by direct derepression of H-NS, mcpA induction requires neither H-NS derepression nor the flagellar-specific sigma factor fliA; instead it occurs through a HilD-SprB regulatory cascade, pro

SUBMITTER: Cooper KG 

PROVIDER: S-EPMC11980550 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature