<i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism.

ABSTRACT: Prolonged cultivation of certain filamentous fungi, including Aspergillus terreus, on drug-free medium leads to degeneration and morphological heterogeneity, marked by the emergence of fluffy mycelium-type sectors. This phenomenon may indicate alterations in antifungal susceptibility profiles (particularly to amphotericin B (AmB) in A. terreus), as well as reductions or losses in conidiation, sexuality, secondary metabolite production, and/or virulence. In the present study, various characteristics of an AmB-resistant wild-type (WT) strain and its AmB-susceptible sectorized derivative (ATSec) were characterized. Compared to WT, ATSec exhibited increased susceptibility to AmB, reduced sporulation, and comparable sterol contents and virulence in Galleria mellonella. To e

SUBMITTER: Eisele D 

PROVIDER: S-EPMC11980562 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature