<i>Campylobacter jejuni</i> resistance to human milk involves the acyl carrier protein AcpP.

ABSTRACT: Campylobacter jejuni is a common foodborne pathogen worldwide that is associated with high rates of morbidity and mortality among infants in low- to middle-income countries (LMICs). Human milk provides infants with an important source of nutrients and contains antimicrobial components for protection against infection. However, recent studies, including our own, have found significantly higher levels of Campylobacter in diarrheal stool samples collected from breastfed infants compared to non-breastfed infants in LMICs. We hypothesized that C. jejuni has unique strategies to resist the antimicrobial properties of human milk. Transcriptional profiling found human milk exposure induces genes associated with ribosomal function, iron acquisition, and amino acid utilization i

SUBMITTER: Zhou B 

PROVIDER: S-EPMC11980577 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature