Assessment of genetic diversity, tissue tropism, and antigenic properties of Grimso betacoronavirus in Swedish bank voles (<i>Clethrionomys glareolus</i>).

ABSTRACT: Zoonotic coronaviruses can transmit over species barriers and infect humans. To understand the zoonotic potential of a betacoronavirus, Grimsö virus (GRIV), we investigated the geographic distribution and tissue tropism of GRIV in Swedish bank voles (Clethrionomys glareolus), and the antigenicity of the nucleocapsid (N) protein. We screened the lung tissues from animals collected in the southern Sweden by RT-PCR with primers targeting the spike gene. Seven out of 74 animals were found to be positive. They are genetically close to GRIV from Grimsö, central Sweden. Positive rodents were studied for the tissue distribution of GRIV and GRIV RNA was mainly found in the respiratory tract. After three attempts of virus isolation were failed, we successfully established a Vero E6 cell line

SUBMITTER: Fernandez Morente S 

PROVIDER: S-EPMC11980623 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature