Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome.

ABSTRACT:

Introduction

The placenta produces corticotrophin releasing hormone (CRH), which rises exponentially in maternal plasma across pregnancy. CRH plays a functional role in fetal development, labor initiation, and the regulation of gestational length. We aimed to understand how maternal plasma CRH during pregnancy reflects placental physiology during parturition by characterizing placental transcriptomic signatures of maternal plasma CRH and comparing to transcriptomic signatures of gestational age at birth.

Methods

Maternal plasma CRH concentrations were measured via radioimmunoassay at two timepoints and the placental transcriptome was quantified via RNA sequencing in 516 pregnant participants enrolled in the CANDLE cohort. Robust linear models were fitted to estimate associat

SUBMITTER: Paquette A 

PROVIDER: S-EPMC11980646 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature