Dual targeting PET tracer [⁶⁸Ga]Ga-PSFA-01 in patients with prostate cancers: A pilot exploratory study.

ABSTRACT: Purpose: To assess the effectiveness of [⁶⁸Ga]Ga-PSFA-01 PET/CT in detecting primary tumors and metastatic lesions in patients with prostate cancer (PCa), and to compare the results with those from [⁶⁸Ga]Ga-PSMA-11 PET/CT and [⁶⁸Ga]Ga-FAPI-04 scans. Methods: Patients with histologically proven PCa were prospectively recruited and underwent [⁶⁸Ga]Ga-PSFA-01 PET/CT, of which: 25 participants also underwent [⁶⁸Ga]Ga-PSMA-11 PET/CT scan, 5 patients also underwent [⁶⁸Ga]Ga-FAPI-04 PET/CT scan, 3 patients underwent three modalities imaging. To assess the expression of PSMA and FAP, we obtained a pathological tissue section from a patient and performed immunohistochemical staining analysis. SUV_max-PSFA, SUV

SUBMITTER: Li Y 

PROVIDER: S-EPMC11980653 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature