Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.

ABSTRACT:

Background

Environmental contamination by endocrine-disrupting chemicals (EDCs) has created serious public health, ecological, and regulatory concerns. Prenatal exposures can affect a wide range of developing organ systems and are associated with adverse changes to behavior, metabolism, fertility, and disease risk in the adult. The most serious and puzzling observation for some EDC exposures is the transmission of effects to subsequent unexposed generations (transgenerational effects) in animal models. This requires the induction of epigenetic aberrations to the germline that are not subject to the normal processes of erasure and resetting in subsequent generations. Understanding when and how the germline is vulnerable to environmental contaminants is an essential first step in dev

SUBMITTER: Vrooman LA 

PROVIDER: S-EPMC11980919 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature