In vitro and in silico pharmaco-nutritional assessments of some lesser-known Nigerian nuts: Persea americana, Tetracarpidium conophorum, and Terminalia catappa.

ABSTRACT: Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, and Terminalia cattapa kernels were evaluated in vitro and in silico. RBC membrane stabilisation for anti-inflammatory characteristics, antioxidant activities by ABTS, DPPH, H2O2, and nitric oxide scavenging assays, and α-glucosidase and α-amylase inhibitory assays conducted in vitro were used to evaluate the anti-diabetic activity. With an IC50 value of 208 μg/mL, P. americana showed the maximum amount of inhibition, according to the results, while T. catappa showed a somewhat lower degree of inhibition at 236 μg/mL. P. americana exhibited the highest degree of α-amylase inhibition, with an IC50 value of 312 µg/mL. T.

SUBMITTER: Eyong ED 

PROVIDER: S-EPMC11981145 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature