Map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration.

ABSTRACT: Proper stem cell targeting and differentiation is necessary for regeneration to succeed. In organisms capable of whole body regeneration, considerable progress has been made identifying wound signals initiating this process, but the mechanisms that control the differentiation of progenitors into mature organs are not fully understood. Using the planarian as a model system, we identify a novel function for map3k1, a MAP3K family member possessing both kinase and ubiquitin ligase domains, to negatively regulate terminal differentiation of stem cells during eye regeneration. Inhibition of map3k1 caused the formation of multiple ectopic eyes within the head, but without controlling overall head, brain, or body patterning. By contrast, other known regulators of planarian eye patterning like wnt

SUBMITTER: Lo KC 

PROVIDER: S-EPMC11981174 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature