Comprehensive characterization of respiratory genes based on a computational framework in pan-cancer to develop stratified treatment strategies.

ABSTRACT: Abnormal cellular respiration plays a critical role in carcinogenesis. However, the molecular mechanisms underlying dysregulation of respiratory gene expression across different cancer types remain unclear. Here, we developed a computational framework that provides an analytical approach for exploring the molecular alterations and clinical relevance of respiratory genes in pan-cancer. We identified a total of 53 gene signatures in the three stages of respiration (including glycolysis, tricarboxylic acid cycle, and oxidative phosphorylation) through this framework and found that they were broadly differentially expressed and genetically altered across 33 cancer types. Pathway analysis manifested that the expression levels of almost all respiratory gene signatures were remarkably associated

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11981224 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature