Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI.

ABSTRACT:

Objective

Thalamic tissue damage in multiple sclerosis (MS) follows a 'surface-in' gradient from the ventricular surface. The clinical consequences of this gradient are not completely understood. Using quantitative gradient-recalled echo (qGRE) MRI, we evaluated a periventricular thalamic gradient of tissue integrity in MS and its relationship with clinical variables.

Methods

Structural and qGRE MRI scans were acquired for a cohort of MS patients and healthy controls (HC). qGRE-derived R2t* values were used as a measure of tissue integrity. Thalamic segmentations were divided into 1-mm concentric bands radiating from the ventricular surface, excluding the CSF-adjacent band. Median R2t* values within these bands were used to calculate the periventricular thalamic gradient.

SUBMITTER: Samara A 

PROVIDER: S-EPMC11981711 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature