Expression of relaxin-3 and its receptors in the hypothalamic-pituitary-ovary axis in layers and broiler breeders.

ABSTRACT: Layers can regulate their feed intake and maintain well-organized ovaries. Conversely, broiler breeders are prone to overeating, leading to disorganized ovaries. Relaxin-3 (RLN3) is a neuropeptide hormone involved in metabolism, energy balance, and reproduction in mammals. In chickens, RLN3 was identified in the ovary, pituitary gland, and hypothalamus. This study aimed to explore the potential role of RLN3 in feeding behavior and reproduction. Expression of RLN3 and relaxin family peptide receptors (RXFP1 and 3) were examined in ovarian follicles, the pituitary gland, and the hypothalamus between layers (L) and broiler breeders (BB). Gene expression analysis revealed RLN3 was highest in the granulosa cells (GC) of 9-12 mm follicles compared with other follicles, with BB had the highest ov

SUBMITTER: Boukherroub K 

PROVIDER: S-EPMC11981738 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature