Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in <i>Xenopus</i> oocytes.

ABSTRACT: The relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic strategies to mitigate the effects of oxidative stress on inhibitory neurotransmission in various neurological disorders. Inhibitory glycine receptors play a critical role in regulating the final grand postsynaptic potential by attenuating excitatory postsynaptic potentials through inhibitory postsynaptic potentials in postsynaptic neurons. This is particularly important in rapid signal transmission systems, where it determines whether the grand postsynaptic potential exceeds the activation threshold. Glycine receptors are known to be expr

SUBMITTER: Eom S 

PROVIDER: S-EPMC11981762 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature