Could blastocysts derived from abnormal fertilized zygotes be used? A systematic review and meta-analysis.

ABSTRACT:

Objectives

Current guidelines advise against using embryos derived from mono-pronuclei (1PN) or non-pronuclei (0PN) zygotes for clinical purposes. Nevertheless, recent studies have demonstrated that 1PN and 0PN zygotes can lead to healthy births. This study aimed to investigate the pregnancy outcomes of 1PN and 0PN blastocysts.

Methods

PubMed, EMBASE, Web of Science and Cochrane databases were searched up to 14 March 2024. Eligible studies enrolled participants transferring 0PN or 1PN blastocysts, with two pronuclei (2PN) blastocysts used as the control. Clinical pregnancy rate, miscarriage rate and live birth rate were the main outcomes. The results were presented as odds ratios (OR) with 95 % confidence intervals (CI) using random-effect models with the Mantel-Haenszel met

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11981765 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature