Misclassification of second primary and recurrent breast cancer in the surveillance epidemiology and end results registry.

ABSTRACT: The Surveillance Epidemiology and End Results (SEER) registry incorporates laterality, histology, latency, and topography to identify second primary breast cancers. Contralateral tumors are classified as second primaries, but ipsilaterals are subject to additional inclusion criteria that increase specificity but may induce biases. It is important to understand how classification methods affect accuracy of second tumor classification. We collected estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, Her2) status for 11,838 contralateral and 5,371 ipsilateral metachronous secondary tumors and estimated concordance odds ratios (cORs) to evaluate receptor dependence (the tendency for tumors to share receptor status) by laterality. If only second primaries are included,

SUBMITTER: Van Alsten SC 

PROVIDER: S-EPMC11981851 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature