Reproducibility of the Determination of ¹³C-Labeling of Glutamate and Glutamine in the Human Brain Using selPOCE-MRS at 7 T Upon [U-¹³C]-Labeled Glucose Infusion.

ABSTRACT: Glutamate (Glu) is the major excitatory neurotransmitter in the central nervous system. The measurement of Glu/glutamine (Gln) neurotransmitters in the brain provides valuable insights into the dynamic aspects of neuroenergetics and neurotransmitter cycles and can be accomplished through the detection of ¹³C-labeling of Glu and Gln during the administration of ¹³C-labeled glucose. Our goal is to evaluate the reproducibility of selective proton-observed, carbon-edited (selPOCE) MRS at 7 T for the detection of ¹³C-labeled Glu and Gln in the human brain. Data of three healthy participants, who were scanned twice at 7 T while undergoing [U-¹³C]-glucose infusion for 120 min, were used to detect ¹³C-labeled Glu and Gln in the brain, using se

SUBMITTER: Ahmadian N 

PROVIDER: S-EPMC11981885 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature